| Bioactivity | SP4206 is an IL-2/IL-2Rα interaction inhibitor. SP4206 binds with high affinity (Kd=70 nM) to IL-2 and blocks binding to its natural receptor IL-2Rα (Kd=10 nM)[1]. | ||||||||||||
| Invitro | SP4206 binds the WT IL-2, IL-2 variant K35L/M39V, IL-2 variant P65A, and IL-2 variant V69A with EC50s of 68.8, 80.1, 117.0, and 10.4 nM, respectively[1]. | ||||||||||||
| Name | SP4206 | ||||||||||||
| CAS | 515846-21-6 | ||||||||||||
| Formula | C30H37Cl2N7O6 | ||||||||||||
| Molar Mass | 662.56 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Thanos CD, et al. Hot-spot mimicry of a cytokine receptor by a small molecule. Proc Natl Acad Sci U S A. 2006 Oct 17;103(42):15422-7. |
SP4206
CAS: 515846-21-6 F: C30H37Cl2N7O6 W: 662.56
SP4206 is an IL-2/IL-2Rα interaction inhibitor. SP4206 binds with high affinity (Kd=70 nM) to IL-2 and blocks binding t
Data collection：peptidedb@qq.com
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