| Bioactivity | SP3N is a specific degrader of proline isomerase FKBP12, which is metabolized by amine oxidase to a precursor of the active aldehyde (SP3CHO), which recruits SCFFBXO22 ligase for FKBP12 degradation. SP3N can be used in cancer therapy research[1]. |
| Formula | C39H57N3O10 |
| Molar Mass | 727.88 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kagiou C, et al. Alkylamine-tethered molecules recruit FBXO22 for targeted protein degradation[J]. Nature Communications, 2024, 15(1): 5409. |