| Bioactivity | SP100030 analogue 1 (compound 11), a SP100030 (HY-110177) analogue, is a selective inhibitor of transcriptional activation (SITA) with an EC50 of 137 nM for suppressing the XPO1-dependent upregulation of IL2 by Jurkat-based IL2-Luc reporter assay[1]. |
| CAS | 154934-68-6 |
| Formula | C13H5ClF7N3O |
| Molar Mass | 387.64 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yi Fan Chen, et al. Electrophile Determines Cellular Phenotypes among XPO1-Targeting Small Molecules. J Med Chem. 2024 Jul 25;67(14):12033-12054. |
SP100030 analogue 1
CAS: 154934-68-6 F: C13H5ClF7N3O W: 387.64
SP100030 analogue 1 (compound 11), a SP100030 (HY-110177) analogue, is a selective inhibitor of transcriptional activati
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