| Bioactivity | SORT-PGRN interaction inhibitor 1 is a potent inhibitor of the sortilin-progranulin interaction with an IC50 of 2 μM[1]. | ||||||||||||
| Target | IC50: 2 μM (Sortilin-progranulin interaction) | ||||||||||||
| Invitro | SORT-PGRN interaction inhibitor 1 (Compound 2) with sufficient potency and physicochemical properties to enable co-crystallization with sortilin[1]. | ||||||||||||
| Name | SORT-PGRN interaction inhibitor 1 | ||||||||||||
| CAS | 100957-85-5 | ||||||||||||
| Formula | C15H18N2O2 | ||||||||||||
| Molar Mass | 258.32 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Shawn J Stachel, et al. Identification of potent inhibitors of the sortilin-progranulin interaction. Bioorg Med Chem Lett. 2020 Sep 1;30(17):127403. |
SORT-PGRN interaction inhibitor 1
CAS: 100957-85-5 F: C15H18N2O2 W: 258.32
SORT-PGRN interaction inhibitor 1 is a potent inhibitor of the sortilin-progranulin interaction with an IC50 of 2 μM.
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