SOD1-Derlin-1 inhibitor-2_product_DataBase

CAS: 2170170-27-9 F: C22H18N4OS W: 386.47

SOD1-Derlin-1 inhibitor-2 (compound 56-59) is an inhibitor of SOD1-Derlin-1 interaction. SOD1-Derlin-1 inhibitor-2 atten

This product is for research use only, not for human use. We do not sell to patients.

Bioactivity

SOD1-Derlin-1 inhibitor-2 (compound 56-59) is an inhibitor of SOD1-Derlin-1 interaction. SOD1-Derlin-1 inhibitor-2 attenuates the interactions between Derlin-1 and SOD1mut. SOD1-Derlin-1 inhibitor-2 can be used for the research of amyotrophic lateral sclerosis (ALS)[1].

Invitro

SOD1-Derlin-1 inhibitor-2 (compound 56-59; 0.1-100 μM) 以剂量依赖性方式抑制 SOD1-Derlin-1 相互作用[1]。

In Vivo

SOD1-Derlin-1 inhibitor-2 (compound 56-59; i.c.v.; 3 mM, 流速 0.15 μL/h) 改善 ALS 模型小鼠的 ALS 病理[1]。 Animal Model:

Name

SOD1-Derlin-1 inhibitor-2

CAS

2170170-27-9

Formula

C22H18N4OS

Molar Mass

386.47

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Tsuburaya N, et al. A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model. Nat Commun. 2018 Jul 10;9(1):2668.

PeptideDB

SOD1-Derlin-1 inhibitor-2

CAS: 2170170-27-9 F: C22H18N4OS W: 386.47