| Bioactivity | SOD1-Derlin-1 inhibitor-1 (compound 56-20) is an inhibitor of SOD1-Derlin-1 interaction. SOD1-Derlin-1 inhibitor-1 inhibits SOD1G93A-Derlin-1 complex with an IC50 value of 7.11 μM. SOD1-Derlin-1 inhibitor-1 can be used for the research of amyotrophic lateral sclerosis[1]. |
| Target | IC50: 7.11 μM (SOD1G93A-Derlin-1 complex) |
| Invitro | SOD1-Derlin-1 inhibitor-1 (50 μM; 16 h) inhibits SOD1G93A-Derlin-1 complex with an IC50 value of 7.11 μM[1]. SOD1-Derlin-1 inhibitor-1 (250 nM; 6 h) interacts with SOD1G93A with a Kd value of 81.1 μM[1]. |
| Name | SOD1-Derlin-1 inhibitor-1 |
| CAS | 840461-03-2 |
| Formula | C19H12Br2N4OS |
| Molar Mass | 504.20 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Tsuburaya N, et al. A small-molecule inhibitor of SOD1-Derlin-1 interaction ameliorates pathology in an ALS mouse model. Nat Commun. 2018 Jul 10;9(1):2668. |
SOD1-Derlin-1 inhibitor-1
CAS: 840461-03-2 F: C19H12Br2N4OS W: 504.20
SOD1-Derlin-1 inhibitor-1 (compound 56-20) is an inhibitor of SOD1-Derlin-1 interaction. SOD1-Derlin-1 inhibitor-1 inhib
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