| Bioactivity | SN-398 is a derivative of camptothecin (CPT), which is an antitumor drug. Acting by inhibiting mammalian DNA topoisomerase I (Topo I), stabilizing the Topo I-DNA complex prevents DNA rewiring to induce Topo I mediated DNA breaks. In Hela cell tests, SN-398 shows stronger antitumor activity than SN-38 (HY-13704) (IC50=1.562±0.4 μM). SN-398 can be used to study the anti-proliferation and growth inhibition of Topo I in cancer cells[1]. |
| CAS | 124623-00-3 |
| Formula | C22H19FN2O5 |
| Molar Mass | 410.40 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yoshikawa M, et al. Novel camptothecin analogues that circumvent ABCG2‐associated drug resistance in human tumor cells[J]. International journal of cancer, 2004, 110(6): 921-927. |