| Bioactivity | SN-38 (NK012) is an active metabolite of the Topoisomerase I inhibitor Irinotecan. SN-38 (NK012) inhibits DNA and RNA synthesis with IC50s of 0.077 and 1.3 μM, respectively[1][2][3][4]. | ||||||||||||
| Invitro | The IC50 values for LoVo, HCT116, and HT29 cell lines is 20 nM, 50 nM, 130 nM, respectively. In all three SN-38 (NK012) resistant cell lines Top1 activity is maintained in the presence of high concentrations of SN-38[2]. | ||||||||||||
| Name | SN-38 | ||||||||||||
| CAS | 86639-52-3 | ||||||||||||
| Formula | C22H20N2O5 | ||||||||||||
| Molar Mass | 392.40 | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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