| Bioactivity | SMase-IN-1 (Compound 4) is a bacterial sphingomyelinase enzyme (SMase) inhibitor (IC50 value for B. cereus SMase is 6.43 µM). SMase-IN-1 also inhibits eqBuChE (59.50% inhibition rate at 50 µM concentration). SMase-IN-1 forms a complex with Cu2+ in biometal interactions. SMase-IN-1 reduces B. cereus-induced hemolysis on sheep erythrocytes[1]. |
| CAS | 33017-85-5 |
| Formula | C8H5ClN2OS |
| Molar Mass | 212.66 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Ozturk OK, et al. Quinazoline derivatives as novel bacterial sphingomyelinase enzyme inhibitors. Bioorg Chem. 2025 Jan;154:108079. |
SMase-IN-1
CAS: 33017-85-5 F: C8H5ClN2OS W: 212.66
SMase-IN-1 (Compound 4) is a bacterial sphingomyelinase enzyme (SMase) inhibitor (IC50 value for B. cereus SMase is 6.43
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