| Bioactivity | SMYD3-IN-2 is a SMYD3 inhibitor against gastric cancer via inducing lethal autophagy. SMYD3-IN-2 has inhibitory for SMYD3 and BGC823 cells with IC50 values of 0.81 μM and 0.75 μM, respectively. SMYD3-IN-2 can be used for the research of cancer[1]. |
| Invitro | SMYD3-IN-2 (compound 7r) (1.0 μM) 对 SMYD3 和 BGC823 细胞表现出强效抑制能力，IC50 值分别为 0.81 μM和 0.75 μM[1] .SMYD3-IN-2 (1.0 μM; 24 h) 可抑制 SMYD3 引起的 Akt 甲基化和激活[1]。SMYD3-IN-2 (0-48 h) 通过诱导自噬性细胞死亡抑制 BGC823 胃腺癌细胞的增殖[1]。 Western Blot Analysis[1] Cell Line: |
| In Vivo | SMYD3-IN-2 (compound 7r) (i.p.; 15 and 30 mg/kg) suppresses the growth of BGC823 xenograft models in vivo[1]. Animal Model: |
| Name | SMYD3-IN-2 |
| Formula | C26H21BrN2O4 |
| Molar Mass | 505.36 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hong-Ping Zhu, et al. Discovery of tetrahydrofuranyl spirooxindole-based SMYD3 inhibitors against gastric cancer via inducing lethal autophagy. Eur J Med Chem. 2023 Jan 15;246:115009. |