| Bioactivity | SMS2-IN-1 is a potent and highly selective sphingomyelin synthase 2 (SMS2) inhibitor with an IC50 of 6.5 nM and a Kd of 37 nM. SMS2-IN-1 shows 150-fold selectivity for SMS2 over SMS1 (IC50 of 1000 nM)[1]. | ||||||||||||
| Target | IC50: 6.5 nM (SMS2), 1000 nM (SMS1)Kd: 37 nM (SMS2) | ||||||||||||
| Invitro | AS/MS binding experiments are conducted using these SMS2-mutant membrane fractions, SMS2-IN-1 (compound 2) binds to the S217A, H272A, and D276A mutants. S227 and H229 are pivotal amino acid residues for the binding of SMS2-IN-1 to SMS2[1]. | ||||||||||||
| Name | SMS2-IN-1 | ||||||||||||
| CAS | 2098890-15-2 | ||||||||||||
| Formula | C34H37F6N3O5 | ||||||||||||
| Molar Mass | 681.67 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Adachi R, et al. Discovery and characterization of selective human sphingomyelin synthase 2 inhibitors. Eur J Med Chem. 2017 Aug 18;136:283-293. |
SMS2-IN-1
CAS: 2098890-15-2 F: C34H37F6N3O5 W: 681.67
SMS2-IN-1 is a potent and highly selective sphingomyelin synthase 2 (SMS2) inhibitor with an IC50 of 6.5 nM and a Kd of
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