| Bioactivity | SMIP34 is a PELP1 inhibitor. SMIP34 binds to PELP1 with a Kd of 37.4 μM. SMIP34 inhibits cancer cell proliferation and tumor progression. SMIP34 can be used for breast cancer research, and is active against wild-type (WT), mutant (MT) ER+ and therapy-resistant (TR)-ER+ breast cancer[1]. |
| CAS | 1189710-20-0 |
| Formula | C25H32ClN5O3 |
| Molar Mass | 486.01 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Altwegg KA, et al. A First-in-Class Inhibitor of ER Coregulator PELP1 Targets ER+ Breast Cancer. Cancer Res. 2022 Oct 17;82(20):3830-3844. |
SMIP34-6
CAS: 1189710-20-0 F: C25H32ClN5O3 W: 486.01
SMIP34 is a PELP1 inhibitor. SMIP34 binds to PELP1 with a Kd of 37.4 μM. SMIP34 inhibits cancer cell proliferation and
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This product is for research use only, not for human use. We do not sell to patients.