| Bioactivity | SMIP-031 is a potent and orally active PPM1A inhibitor with an IC50 value of 180 nM. SMIP-031 induces autophagy. SMIP-031 inhibits Mycobacterium tuberculosis infect in mice[1]. |
| Target | IC50: 180 nM (PPM1A) |
| Invitro | SMIP-031 (0.5, 1, 2.5,5 µM; 5 days) 以剂量依赖性方式减少受感染的 THP-1 细胞中的 Mycobacterium tuberculosis (Mtb) 的负担[1]。SMIP-031 (0.25, 0.5, 1, 2, 4, 8 µM) 通过降低 Mtb 感染的 THP-1 巨噬细胞中 S403-p62 的蛋白表达来诱导自噬[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> SMIP-031 相关抗体: Western Blot Analysis[1] Cell Line: |
| In Vivo | SMIP-031 (12.5, 50 mg/kg; i.p.; daily for 8 days) 可降低受感染小鼠脾脏中的细菌负担[1].药代动力学分析 (ICR (CD-1) mice; i.v. for 2 mg/kg; p.o. for 10 mg/kg)[1]. administration |
| Formula | C17H17BrFNO2 |
| Molar Mass | 366.22 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yu Z, et al. Small Molecule Targeting PPM1A Activates Autophagy for Mycobacterium tuberculosis Host-Directed Therapy. J Med Chem. 2024 Jul 3. |