| Bioactivity | SMARCA2-IN-6 is a SMARCA2 (also known as BRM) inhibitor, with IC50s less than 5 nM for SMARCA2 and SMARCA4. SMARCA2-IN-6 inhibits KRT80 gene expression in H1299 cells (IC50: 26 nM). SMARCA2-IN-6 inhibits proliferation in BRG1-mutant SKMEL5 cells (IC50: 13 nM)[1]. |
| CAS | 2270875-79-9 |
| Formula | C10H8ClF2N5OS |
| Molar Mass | 319.72 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Papillon JPN, et al. Discovery of Orally Active Inhibitors of Brahma Homolog (BRM)/SMARCA2 ATPase Activity for the Treatment of Brahma Related Gene 1 (BRG1)/SMARCA4-Mutant Cancers. J Med Chem. 2018 Nov 21;61(22):10155-10172. |
SMARCA2-IN-6
CAS: 2270875-79-9 F: C10H8ClF2N5OS W: 319.72
SMARCA2-IN-6 is a SMARCA2 (also known as BRM) inhibitor, with IC50s less than 5 nM for SMARCA2 and SMARCA4. SMARCA2-IN-6
Sales Email：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.