| Bioactivity | SLX-4090 is an orally active enterocytic-specific microsomal triglyceride transfer protein (MTP) inhibitor with an IC50 of 8.0 nM. SLX-4090 can be used for the research of dyslipidemia[1]. |
| Invitro | SLX-4090 inhibits apolipoprotein B (IC50 value 9.6 nM) but not apolipoprotein A1 secretion in Caco-2 cells[1]. |
| In Vivo | SLX-4090 (orally, 30 mg/kg) reduces postprandial lipids by 50% with an ED50 value 7 mg/kg in rats[1]. |
| Name | SLX-4090 |
| CAS | 913541-47-6 |
| Formula | C31H25F3N2O4 |
| Molar Mass | 546.54 |
| Appearance | Solid |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |
| Reference | [1]. Enoch Kim, et al. A small-molecule inhibitor of enterocytic microsomal triglyceride transfer protein, SLx-4090: biochemical, pharmacodynamic, pharmacokinetic, and safety profile. J Pharmacol Exp Ther. 2011 Jun;337(3):775-85. |
SLX-4090
CAS: 913541-47-6 F: C31H25F3N2O4 W: 546.54
SLX-4090 is an orally active enterocytic-specific microsomal triglyceride transfer protein (MTP) inhibitor with an IC50
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