SLU-PP-915_product_DataBase

Bioactivity	SLU-PP-915 is an agonist of ERR. SLU-PP-915 has an EC50 value of approximately 400 nM for ERRα, ERRβ, and ERRγ. SLU-PP-915 has potential application in maintaining oxidative metabolism and heart failure[1][2][3].
Invitro	SLU-PP-915 (2.5 µM；72 h) 增加新生大鼠心室肌细胞 (NRVMs) 中转录因子 EB (TFEB) 的基因和蛋白表达[3]。SLU-PP-915 (5 µM) 增加 C2C12 细胞中 TFEB 基因 (3 h 时) 和 TFEB 蛋白 (72 h 时) 的表达[3]。SLU-PP-915 (5 µM；48 h 或 72 h) 增加 C2C12 细胞中 ERR 靶向基因 PGC1a、p62、PDK4、CTSD、LAMP1、LAMP2 和 MCOLN1 的表达[3]。 Western Blot Analysis[3] Cell Line:
In Vivo	SLU-PP-915 在成年雄性小鼠中改善了经皮质收缩 (TAC) 诱导的心力衰竭[1]。SLU-PP-915 在6周压力过载的小鼠心脏中，使脂肪酸/脂质和 TCA/OXPHOS 代谢产物的代谢谱显著正常化。SLU-PP-915 在不影响心肌肥厚的情况下改善了 TAC 诱导心力衰竭的体内泵血功能[2]。 Animal Model:
Name	SLU-PP-915
CAS	2285432-92-8
Formula	C17H13BFNO3S
Molar Mass	341.16
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Xu W, et al. The Cardiac Protective Effects of Novel Synthetic Pan-Estrogen Related Receptor Agonists Slu-pp-332 and Slu-pp-915[J]. Circulation, 2021, 144(Suppl_1): A9682-A9682. [2]. Xu W, et al. Novel ERR pan-agonists ameliorate heart failure through boosting cardiac fatty acid metabolism and mitochondrial function[J]. bioRxiv, 2022: 2022.02. 14.480431. [3]. Losby M K, et al. The Estrogen Receptor-Related Orphan Receptors (ERRs) Regulate Autophagy through TFEB[J]. bioRxiv, 2023: 2023.03. 02.530836.

PeptideDB

SLU-PP-915

CAS: 2285432-92-8 F: C17H13BFNO3S W: 341.16