SLC26A3-IN-2_product_DataBase

Bioactivity	SLC26A3-IN-2 is an orally active inhibitor of anion exchanger protein SLC26A3 (IC50=360 nM). SLC26A3 belongs to solute carrier (SLC) proteins, and the SLC26 family. SLC26 family has broad anion specificity for chloride, bicarbonate, sulfate and oxalate. SLC26A3 down-regulates in adenoma, DRA, involves in in intestinal absorption of chloride and oxalate. The loss of SLC26A3 function mutations is associated with chloride-losing diarrhea[1].
Invitro	SLC26A3-IN-2 (化合物3a) (10 μM; 10 min) 对 SLC26A3 的抑制率为 92%[1]。
In Vivo	SLC26A3-IN-2 (10 mg/kg；口服) 在 Loperamide (HY-B0418A) 诱导的小鼠便秘模型中显著增加粪便重量和颗粒数量，证明其增加小鼠粪便水化的功效[1]。
Name	SLC26A3-IN-2
CAS	950348-60-4
Formula	C19H13ClN2O2S
Molar Mass	368.84
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Cil O, et al. Small molecule inhibitors of intestinal epithelial anion exchanger SLC26A3 (DRA) with a luminal, extracellular site of action. Eur J Med Chem. 2023 Mar 5;249:115149.

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