| Bioactivity | SKI-I is a potent and selective inhibitor of human sphingosine kinase (SK), with an IC50 of 1.2 μM for ST-hSK. SKI-I also inhibits hERK2 (IC50=11 μM). SKI-I induces apoptosis in tumor cell lines[1][2]. |
| Invitro | SKI-I (Compound I; 5 μg/mL) inhibits SK activity by 99%[1].SKI-I (10 μM; 24 h) induces the apoptosis of T24 cells[1]. |
| Name | SKI-I |
| CAS | 306301-68-8 |
| Formula | C25H18N4O2 |
| Molar Mass | 406.44 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, protect from light *In solvent : -80°C, 6 months; -20°C, 1 month (protect from light) |