SKF-82958 hydrobromide_product_DataBase

Bioactivity	SKF-82958 ((±)-SKF 82958) hydrobromide is a dopamine D1 receptor full agonist (K0.5=4 nM), displays selective for D1 over D2 receptors (K0.5=73 nM). SKF-82958 hydrobromide induces dopamine D1 receptor-dependent adenylate cyclase activity in rat striatal membranes (EC50=491 nM)[1].
In Vivo	SKF-82958 ((±)-SKF 82958) hydrobromide (0.003-0.1 mg/kg; i.p.) results in dose-dependent increases in responding on the SKF-82958 appropriate lever, with full substitution following administration of the SKF-82958 hydrobromide training dose 0.03 mg/kg. Increasing the dose of SKF-82958 hydrobromide also results in a significant reduction in response rate[2].SKF-82958 hydrobromide (0.5-2.0 mg/kg; i.p) significantly suppresses pilocarpine-induced jaw movements[3]. Animal Model:
Name	SKF-82958 hydrobromide
CAS	74115-01-8
Formula	C19H21BrClNO2
Molar Mass	410.73
Appearance	Solid
Transport	Room temperature in continental US; may vary elsewhere.
Storage	4°C, sealed storage, away from moisture *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)
Reference	[1]. Mottola DM, et al. Conformational analysis of D1 dopamine receptor agonists: pharmacophore assessment and receptor mapping. J Med Chem. 1996;39(1):285-296. [2]. Haile CN, et al. The dopamine D(1) receptor agonist SKF-82958 serves as a discriminative stimulus in the rat. Eur J Pharmacol. 2000;388(2):125-131. [3]. Mayorga AJ, et al. Striatal and nigral D1 mechanisms involved in the antiparkinsonian effects of SKF 82958 (APB): studies of tremulous jaw movements in rats. Psychopharmacology (Berl). 1999;143(1):72-81.

PeptideDB

SKF-82958 hydrobromide

CAS: 74115-01-8 F: C19H21BrClNO2 W: 410.73