| Bioactivity | SKF 81297 is a potent and selective dopamine D1 receptor agonist[1]. |
| In Vivo | SKF 81297 (0.05-0.3 mg/kg，肌注，一次) 刺激 MPTP 损伤猴子的运动行为[1]。 Animal Model: |
| Name | SKF 81297 |
| CAS | 71636-61-8 |
| Formula | C16H16ClNO2 |
| Molar Mass | 289.76 |
| Appearance | 固体 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | 4°C, sealed storage, away from moisture and light *In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light) |
| Reference | [1]. Vermeulen RJ, et al. The selective dopamine D1 receptor agonist, SKF 81297, stimulates motor behaviour of MPTP-lesioned monkeys. Eur J Pharmacol. 1993 Apr 22;235(1):143-7. [2]. Auger ML, et al. Amelioration of cognitive impairments induced by GABA hypofunction in the male rat prefrontal cortex by direct and indirect dopamine D1 agonists SKF-81297 and d-Govadine. Neuropharmacology. 2020 Jan 1;162:107844. |