| Bioactivity | SK1-IN-1 is a potent sphingosine kinase 1 (SPHK1) inhibitor with an IC50 of 58 nM. | ||||||||||||
| Target | IC50: 58 nM (SPHK1) | ||||||||||||
| In Vivo | SK1-IN-1 demonstrates significant improvement in the intrinsic clearance, particularly against human liver microsomes. SK1-IN-1 is selected for rat PK studies and demonstrates modest in oral bioavailability with acceptable half-lives in blood circulation[1]. | ||||||||||||
| Name | SK1-IN-1 | ||||||||||||
| CAS | 1218816-71-7 | ||||||||||||
| Formula | C22H30N4O3 | ||||||||||||
| Molar Mass | 398.50 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Xiang Y, et al. Discovery of novel sphingosine kinase-1 inhibitors. Part 2. Bioorg Med Chem Lett. 2010 Aug 1;20(15):4550-4. |