| Bioactivity | SJ572403 (SJ403) is a p27Kip1 inhibitor. SJ572403 has high specificity for specific regions within the D2 subdomain of p27-KID with a Kd value of 2.2 mM. SJ572403 can be used for the research of diseases associated with intrinsically disordered proteins (IDPs)[1]. | ||||||||||||
| Target | Kd: 2.2 mM (p27-KID) | ||||||||||||
| Invitro | SJ572403 (SJ403) (3 mM) shows specific interactions with specific regions within the D2 subdomain of p27-KID with a Kd value of 2.2 mM[1].SJ572403 (0-3 mM) modulates p27's Cdk regulatory[1].SJ572403 (10 μM-3 mM) displaces p27-D2 from Cdk2/cyclin A and partially restores Cdk2 kinase activity[1]. | ||||||||||||
| Name | SJ572403 | ||||||||||||
| CAS | 19970-45-7 | ||||||||||||
| Formula | C13H17N5O2 | ||||||||||||
| Molar Mass | 275.31 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Iconaru LI, et al. Discovery of Small Molecules that Inhibit the Disordered Protein, p27(Kip1). Sci Rep. 2015 Oct 28;5:15686. [2]. Pablo Herrera-Nieto, et al. Small Molecule Modulation of Intrinsically Disordered Proteins Using Molecular Dynamics Simulations. J Chem Inf Model. 2020 Oct 26;60(10):5003-5010. |