| Bioactivity | SJ46421 is a (+)-JQ-1 (HY-13030) based KLHDC2 PROTAC protein degrader. SJ46421 is able to promote a substantially tight ternary complex with KLHDC2 with an IC50 of 7.8 nM. SJ46421 promotes polyubiquitylation of the BD2 domain from BRD2, BRD3, or BRD4 (Pink: ligand for target protein (HY-13030); Black: linker (HY-20797); Blue: E3 ligase ligand (HY-168536))[1]. |
| Formula | C42H41ClN8O5S2 |
| Molar Mass | 837.41 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Daniel C Scott, et al. Principles of paralog-specific targeted protein degradation engaging the C-degron E3 KLHDC2. Nat Commun. 2024 Oct 12;15(1):8829. |