| Bioactivity | SJ1461 is a potent and orally active BET inhibitor. SJ1461 inhibits BRD2 (BD1), and BRD2 (BD2), BRD4 (BD1), and BRD4 (BD2) with IC50 values of 1.6 nM, 0.1 nM, 6.5 nM, and 0.2 nM, respectively[1]. |
| Invitro | SJ1461 抑制 MV4-11、NALM-16、MOLM-13、HDMB03 和 D283 细胞的癌细胞生长，IC50 分别为 20 nM、3.6 nM、10.2 nM、6.6 nM 和 56.2 nM[1] 。 |
| Name | SJ1461 |
| Formula | C21H18ClN7OS2 |
| Molar Mass | 484.00 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Mladen Koravovic, et al. From PROTAC to inhibitor: Structure-guided discovery of potent and orally bioavailable BET inhibitors. Eur J Med Chem. 2023 May 5;251:115246. |