| Bioactivity | SJ1008030 (compound 8) formic is a JAK2 PROTAC which selectively degrades JAK2. SJ1008030 formic inhibits MHH–CALL-4 cell growth with an IC50 of 5.4 nM. SJ1008030 formic can be used for the research of leukemia[1]. |
| Invitro | SJ1008030 (compound 8) formic (72 小时) 在 CRLF2r 细胞系 (MHH-CALL-4) 中显示出活性，IC50 为 5.4 nM[1]。SJ1008030 (0-4.3 μM; 72 小时) formic 在 MHH-CALL-4 细胞中以剂量依赖性方式降解 JAK、GSPT1 和 IKZF1[1]。SJ1008030 (0-10 μM; 24h) formic 剂量依赖性地降解异种移植骨髓细胞 SJBALL021415 中的 JAK2 和 GSPT1 蛋白，表明对 JAK-STAT 信号通路的抑制[1]。 0 --> SJ1008030 formic 相关抗体: |
| Name | SJ1008030 formic |
| Formula | C43H45N13O9S |
| Molar Mass | 919.96 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Chang Y, et al. Degradation of Janus kinases in CRLF2-rearranged acute lymphoblastic leukemia. Blood. 2021 Dec 9;138(23):2313-2326. |