| Bioactivity | SIS3 free base is a potent and selective inhibitor of Smad3 phosphorylation. SIS3 free base inhibits the myofibroblast differentiation of fibroblasts by TGF-β1. SIS3 free base does not affect the phosphorylation of Smad2[1]. | ||||||||||||
| Target | Smad3, ALK-5 | ||||||||||||
| Invitro | SIS3 free base attenuates the TGF-beta1-induced phosphorylation of Smad3 and interaction of Smad3 with Smad4[1]. Western Blot Analysis[1] Cell Line: | ||||||||||||
| Name | SIS3 free base | ||||||||||||
| CAS | 1009104-85-1 | ||||||||||||
| Formula | C28H27N3O3 | ||||||||||||
| Molar Mass | 453.53 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Jinnin M, et al. Characterization of SIS3, a novel specific inhibitor of Smad3, and its effect on transforming growth factor-beta1-induced extracellular matrix expression. Mol Pharmacol. 2006 Feb;69(2):597-607. Epub 2005 Nov 15. |
SIS3 free base
CAS: 1009104-85-1 F: C28H27N3O3 W: 453.53
SIS3 free base is a potent and selective inhibitor of Smad3 phosphorylation. SIS3 free base inhibits the myofibroblast d
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