| Bioactivity | SIRT5 inhibitor 1 is a potent Human Sirtuin 5 deacylase inhibitor, with an IC50 of 0.11 μM. | ||||||||||||
| Target | IC50: 0.11 μM (Sirtuin). | ||||||||||||
| Invitro | SIRT5 inhibitor 1 (compound 49) is a very potent human sirtuin 5 deacylase inhibitor, with an IC50 of 0.11 μM, >100-fold from compound 1[1]. | ||||||||||||
| Name | SIRT5 inhibitor 1 | ||||||||||||
| CAS | 2166487-21-2 | ||||||||||||
| Formula | C31H39FN6O6S2 | ||||||||||||
| Molar Mass | 674.81 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Rajabi N, et al. Mechanism-Based Inhibitors of the Human Sirtuin 5 Deacylase: Structure-Activity Relationship, Biostructural, and Kinetic Insight. Angew Chem Int Ed Engl. 2017 Nov 20;56(47):14836-14841. |