| Bioactivity | SIRT3 activator 2 (compound 2a) is a SIRT3 activator. SIRT3 activator 2 improved the thermal stability of SIRT3 in SH-SY5Y cells, indicating that it can directly bind to SIRT3, has SIRT3 dependency in SH-SY5Y to clear α-Syn. SIRT3 activator 2 improves motor function in Parkinson mice, preventing Parkinson (DA) neuron loss in the substantia nigra in a dose-dependent manner[1]. |
| Invitro | SIRT3 activator 2 (compound 2)(10 μM, 100 μM) 是 SIRT3 激活剂[1]。SIRT3 activator 2 (10 μM; 24h) 提高了 SH-SY5Y 细胞中 SIRT3 的热稳定性 (CETSA)，表明可直接与 SIRT3 结合 (wb)[1]。 SIRT3 activator2 (10 μM; 24h) 在 SH-SY5Y 细胞中通过 SIRT3 依赖性，消除 α-Syn (wb) 来保护神经元[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> SIRT3 activator 2 相关抗体: Western Blot Analysis[1] Cell Line: |
| In Vivo | SIRT3 activator 2 (10，20，40 mg/kg; Intravenous injection (i.v.); 每次一次; 24 天) 改善过表达 α-突触核蛋白诱导的帕金森小鼠的运动功能[1]。SIRT3 activator 2 (10，20，40 mg/kg; 脑部微量注射) 剂量依赖性阻止过表达 α-突触核蛋白诱导的黑质 DA 神经元丢失 (免疫组化)[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C22H24N2O9S |
| Molar Mass | 492.50 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Tongyu Bi, et al. Ligand-Enabled Pd-Catalyzed sp3 C‒H Macrocyclization: Synthesis and Evaluation of Macrocyclic Sulfonamide for the Treatment of Parkinson's Disease. Angewandte Chemie. 2024 Jul 30:e202412296. |