| Bioactivity | SIRT3 activator 1 (Compound 5v) is a SIRT3 activator. SIRT3 activator 1 selectively elevates SIRT3 expression, leading to the upregulation of SOD2 and OPA1 expression, effectively preventing mitochondrial dysfunction, mitigating oxidative stress, and preserving cardiomyocyte viability. SIRT3 activator 1 can be used for research of cardiovascular diseases[1]. |
| Invitro | SIRT3 activator 1 (0-10 μM) 通过激活 SIRT3/SOD2 和 OPA1 通路保护心肌细胞免受 H9c2 细胞中 Doxorubicin (HY-15142A) 诱导的氧化损伤[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> SIRT3 activator 1 相关抗体: |
| Formula | C32H41N2NaO5 |
| Molar Mass | 556.67 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Chen Z, et al. Design, Synthesis, and In Vivo Evaluation of Isosteviol Derivatives as New SIRT3 Activators with Highly Potent Cardioprotective Effects. J Med Chem. 2024 Apr 25;67(8):6749-6768. |