| Bioactivity | SIRT2/6-IN-1 (Compound 5) is a SIRT6/SIRT2 inhibitor, with IC50s of 106 μM and 114 μM. SIRT2/6-IN-1 increases H3K9 acetylation, increases glucose uptake and reduces TNF-α secretion in cells[1]. |
| Target | 106 μM and 114 μM (SIRT6/SIRT2) |
| Name | SIRT2/6-IN-1 |
| CAS | 1214468-35-5 |
| Formula | C19H14N4O5S |
| Molar Mass | 410.40 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Parenti MD, et al. Discovery of novel and selective SIRT6 inhibitors. J Med Chem. 2014 Jun 12;57(11):4796-804. |
SIRT2/6-IN-1
CAS: 1214468-35-5 F: C19H14N4O5S W: 410.40
SIRT2/6-IN-1 (Compound 5) is a SIRT6/SIRT2 inhibitor, with IC50s of 106 μM and 114 μM. SIRT2/6-IN-1 increases H3K9 ace
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