| Bioactivity | SIK-IN-2 (Compound 45) is an inhibitor for salt-inducible kinase (SIK), which inhibits SKI1, SIK2 and SIK3 with IC50s of 0.1, 0.2 and 0.4 nM, respectively. SIK-IN-2 inhibits the release of TNFa with IC50 of 0.5 nM, stimulates the LPS (HY-D1056) -induced IL-10 release with EC50 of 2 nM in human macrophages[1]. |
| CAS | 3033846-20-4 |
| Formula | C22H22N6OS |
| Molar Mass | 418.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Bootsma AN et al., Heterocyclic sik inhibitors. WO2024062360A1. |
SIK-IN-2
CAS: 3033846-20-4 F: C22H22N6OS W: 418.51
SIK-IN-2 (Compound 45) is an inhibitor for salt-inducible kinase (SIK), which inhibits SKI1, SIK2 and SIK3 with IC50s of
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