| Bioactivity | SIJ1777 is a GNF-7 (HY-10943) derivative, possesses potent anti-cancer effects on melanoma cells harboring BRAF class I/II/III mutations. SIJ1777 substantially inhibits the activation of MEK, ERK, and AKT. SIJ1777 remarkably induces apoptosis and significantly blocks migration, invasion, and anchorage-independent growth of melanoma cells harboring BRAF class I/II/II mutations[1]. |
| Invitro | 与 GNF-7 (HY-10943) 相比，SIJ1777 对抗黑色素瘤细胞 (SK-MEL-2、SK-MEL-28、A375、WM3670、WM3629) 的抗增殖活性增强了 2 至 14 倍[1]。无论黑色素瘤细胞中的 BRAF 突变状态如何，SIJ1777 在 1 μM 浓度下完全抑制磷酸化 MEK、-ERK 和 -AKT 水平[1]。SIJ1777 以浓度依赖性方式增加黑色素瘤细胞 (SK-MEL-2、SK-MEL-28、C8161、WM3629) 上的裂解 PARP 水平[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> SIJ1777 相关抗体: |
| CAS | 839707-55-0 |
| Formula | C26H23F3N8O2 |
| Molar Mass | 536.51 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Kim N, et al. Novel and Potent Small Molecules against Melanoma Harboring BRAF Class I/II/III Mutants for Overcoming Drug Resistance. Int J Mol Sci. 2021 Apr 6;22(7):3783. |
SIJ1777
CAS: 839707-55-0 F: C26H23F3N8O2 W: 536.51
SIJ1777 is a GNF-7 (HY-10943) derivative, possesses potent anti-cancer effects on melanoma cells harboring BRAF class I/
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