| Bioactivity | SI-113 is a SGK1 inhibitor, with an IC50 of 600 nM. SI113 induces autophagy[1][2]. |
| Invitro | SI-113 exhibits IC50 values of 10.5, 14.4 and 10.7 μM in GIN8, GIN28 and GCE28 GBM cells[1].SI-113 induces significant increases in caspase-3/7 activation in all GBM cell lines[1].SI-113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells[2]. |
| Name | SI-113 |
| CAS | 1392816-46-4 |
| Formula | C23H24N6O |
| Molar Mass | 400.48 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Marco Radi , et al. A combined targeted/phenotypic approach for the identification of new antiangiogenics agents active on a zebrafish model: from in silico screening to cyclodextrin formulation. Bioorg Med Chem Lett. 2012 Sep 1;22(17):5579-83. [2]. Silvia Matteoni, et al. The kinase inhibitor SI113 induces autophagy and synergizes with quinacrine in hindering the growth of human glioblastoma multiforme cells. J Exp Clin Cancer Res. 2019 May 17;38(1):202. |