SHS4121705

CAS: 2379550-82-8 F: C11H6F3N5O3 W: 313.19

SHS4121705 is an orally effective mitochondrial uncoupling agent with an IC50 of 4.3 μM in L6 myoblasts. SHS4121705 can

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Bioactivity	SHS4121705 is an orally effective mitochondrial uncoupling agent with an IC50 of 4.3 μM in L6 myoblasts. SHS4121705 can be used in the study of non-alcoholic steatohepatitis (NASH)[1].
In Vivo	SHS4121705 (25 mg/kg, 口服, 持续 21 天) 在 STAM 小鼠模型中可降低肝脏甘油三酯水平，改善肝脏标志物[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only.
CAS	2379550-82-8
Formula	C11H6F3N5O3
Molar Mass	313.19
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Salamoun JM, et al. 6-Amino[1,2,5]oxadiazolo[3,4-b]pyrazin-5-ol Derivatives as Efficacious Mitochondrial Uncouplers in STAM Mouse Model of Nonalcoholic Steatohepatitis. J Med Chem. 2020 Jun 11;63(11):6203-6224.