| Bioactivity | SHS206 (compound 6n) is an orally active mitochondrial uncoupler that reduces hepatic triglyceride levels. SHS206 exhibits in vivo efficacy in the GAN mouse model and shows inhibitory effects on metabolic dysfunction-associated steatohepatitis (MASH)[1]. |
| Formula | C14H7F6N3O |
| Molar Mass | 347.22 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Salamoun J M, et al. Design, synthesis, and biological evaluation of imidazo [4, 5-b] pyridine mitochondrial uncouplers for the treatment of metabolic dysfunction-associated steatohepatitis (MASH)[J]. European Journal of Medicinal Chemistry, 2024, 280: 116916. |