| Bioactivity | SHP2-IN-23 (compound 30) is an orally active SHP2 inhibitor (IC50=38 nM) with excellent in vivo efficacy and pharmacokinetic profiles. SHP2-IN-23 inhibits ERK phosphorylation with IC50=5 nM[1]. |
| Target | IC50: 38 nM (SHP2), 5 nM (pERK) |
| Name | SHP2-IN-23 |
| CAS | 2415989-91-0 |
| Formula | C24H23ClN8S |
| Molar Mass | 491.01 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Elsayed M S A et al. Discovery of 5-Azaquinoxaline Derivatives as Potent and Orally Bioavailable Allosteric SHP2 Inhibitors[J]. ACS Medicinal Chemistry Letters, 2023. |
SHP2-IN-23
CAS: 2415989-91-0 F: C24H23ClN8S W: 491.01
SHP2-IN-23 (compound 30) is an orally active SHP2 inhibitor (IC50=38 nM) with excellent in vivo efficacy and pharmacokin
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