| Bioactivity | SHP2-IN-22 is SHP2 allosteric inhibitor with an IC50 value of 17.7 nM. SHP2-IN-22 inhibits the proliferation, migration, and invasion of MIA PaCa-2 pancreatic cancer cells. SHP2-IN-22 can be used for Kirsten rat sarcoma viral oncogene (KRAS) mutant cancer research[1]. |
| Name | SHP2-IN-22 |
| CAS | 2802453-88-7 |
| Formula | C23H22Cl2N8O |
| Molar Mass | 497.38 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hou Q, et al. Identification of a Novel, Potent, and Orally Bioavailable Guanidine-Based SHP2 Allosteric Inhibitor from Virtual Screening and Rational Structural Optimization for the Treatment of KRAS Mutant Cancers. J Med Chem. 2023 Oct 12;66(19):13646-13664. |
SHP2-IN-22
CAS: 2802453-88-7 F: C23H22Cl2N8O W: 497.38
SHP2-IN-22 is SHP2 allosteric inhibitor with an IC50 value of 17.7 nM. SHP2-IN-22 inhibits the proliferation, migration,
Data collection：peptidedb@qq.com
This product is for research use only, not for human use. We do not sell to patients.