| Bioactivity | SHIP2-IN-1 is a potent SHIP2 inhibitor, inhibits SHIP2 activity, with an IC50 of 2 µM. SHIP2-IN-1 blocks GSK3β activation by phosphorylation at the Ser9 residue. SHIP2-IN-1 is used in the research of Alzheimer’s disease[1]. | ||||||||||||
| Target | IC50: 2 µM (SHIP2) | ||||||||||||
| Invitro | SHIP2-IN-1 (Compound 43; 10 µM) significantly inhibits PI(3,4)P2 production in HT22 cells[1]. | ||||||||||||
| Name | SHIP2-IN-1 | ||||||||||||
| CAS | 2252247-80-4 | ||||||||||||
| Formula | C17H13Cl2FN4O | ||||||||||||
| Molar Mass | 379.22 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Lim JW, et al. Identification of crizotinib derivatives as potent SHIP2 inhibitors for the treatment of Alzheimer's disease. Eur J Med Chem. 2018 Sep 5;157:405-422. |
SHIP2-IN-1
CAS: 2252247-80-4 F: C17H13Cl2FN4O W: 379.22
SHIP2-IN-1 is a potent SHIP2 inhibitor, inhibits SHIP2 activity, with an IC50 of 2 µM. SHIP2-IN-1 blocks GSK3β activat
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