| Bioactivity | SH-E4A-66 is a C2-COUPLr (COvalent Protein Ligator) with carbazole scaffold barring heterogeneous cysteine reactive warheads (acrylamide and chloroacetamide). SH-E4A-66 is capable of coupling with EML4-ALK (EC50=1.5 μM) and inhibiting the activity of EML4-ALK kinase (IC50=2.3 µM)[1]. |
| Target | IC50: 2.3 μM (EML4-ALK). |
| Formula | C24H18ClN3O3 |
| Molar Mass | 431.87 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Yang D, et al. Systematic Targeting of Protein Complexes with Molecular COUPLrs[J]. bioRxiv, 2024: 2024.07. 16.603666. |