| Bioactivity | SGP8 (IAVPGEVA) is an octopeptide derived from the hydrolysis of soybean 11S globulin. SGP8 (IAVPGEVA) has the role of regulating lipid metabolism, inflammation and fibrosis. SGP8 (IAVPGEVA) exhibits inhibitory activity against DPP4 and inhibits the JNK-c-Jun signaling pathway. SGP8 (IAVPGEVA) has the ability to inhibit the non-alcoholic steatohepatitis (NASH) [1]. |
| Invitro | SGP8 (0,100 和 500 µM; 24 h) 对脂质代谢，炎症和纤维化具有调节作用[1]。SGP8 (0,100 和 500 µM; 24 h) 显著提高了体内血清 GLP-1 含量， SGP8 对 DPP4 具有抑制活性[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> SGP8 相关抗体: Real Time qPCR[1] Cell Line: |
| In Vivo | SGP8 (15 mg/kg，每天腹腔注射 1 次持续4周) 减轻 MCD 饮食引起的小鼠脂肪性肝炎[1]。SGP8 (15 mg/kg，每天腹腔注射 1 次持续8周) 减轻 HFD 引起的小鼠肝损伤和代谢紊乱[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| CAS | 855790-98-6 |
| Sequence | Ile-Ala-Val-Pro-Gly-Glu-Val-Ala |
| Shortening | IAVPGEVA |
| Formula | C34H58N8O11 |
| Molar Mass | 754.87 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Peng Ma,et al. IAVPGEVA: Orally Available DPP4-Targeting Soy Glycinin Derived Octapeptide with Therapeutic Potential in Nonalcoholic Steatohepatitis.Journal of Agricultural and Food Chemistry. 2024, 72, 13, 7167–7178. |