| Bioactivity | SGE-516 is a neuroactive steroid that is a potent positive allosteric modulator of synaptic and extra-synaptic GABAA receptors. SGE-516 has anticonvulsant activity[1]. |
| In Vivo | SGE-516 (3 mg/kg, 腹腔给药, 单剂量) 对高热诱导的小鼠癫痫发作具有保护作用[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| CAS | 1430064-74-6 |
| Formula | C23H35N3O2 |
| Molar Mass | 385.54 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hawkins NA, et al. The synthetic neuroactive steroid SGE-516 reduces seizure burden and improves survival in a Dravet syndrome mouse model. Sci Rep. 2017 Nov 10;7(1):15327. |