| Bioactivity | SFI003 is a novel SRSF3 inhibitor, and shows anticancer activity by inducing ROS-mediated cell apoptosis against colorectal cancer[1]. |
| Invitro | SFI003 (0-2.5 μM, 72 h) 对 HCT-116 和 SW480细胞的增殖具有抑制作用，IC50 值分别为 8.78µM 和48.67µM[1]。SFI003 (10、20 和 50 μM, 72 h) 诱导 HCT-116 和 SW480 细胞凋亡[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> SFI003 相关抗体: |
| In Vivo | SFI003 (皮下注射，100, 200 mg/kg 连续两周) 抑制 HCT-116 和 SW480 异种移植 SCID 小鼠的肿瘤的生长[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| CAS | 2361332-90-1 |
| Formula | C19H17N5OS |
| Molar Mass | 363.44 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhang Y, et al. A novel SRSF3 inhibitor, SFI003, exerts anticancer activity against colorectal cancer by modulating the SRSF3/DHCR24/ROS axis. Cell Death Discov. 2022 May 2;8(1):238. |