| Bioactivity | SEMBL is a potent NF-κB inhibitor. SEMBL can inhibit NF-κB-DNA binding, and also inhibits NF-κB-dependent inflammatory cytokine secretions. SEMBL inhibits cancer cell migration and invasion via decreasing MMP expression. SEMBL can be used for researching anticancer[1]. | ||||||||||||
| Target | NF-κB, MMP-2 | ||||||||||||
| Invitro | SEMBL inhibits MMP-2 expression and cellular metastatic activity in ovarian carcinoma cells[1].SEMBL inhibits the cell-free DNA binding of NF-κB in the ES-2 nuclear extract and inhibits the constitutively activated NF-κB activity in ovarian carcinoma cells[1].SEMBL inhibits cellular migration, invasion and MMP-2 expression in ovarian carcinoma cells at non-toxic concentrations[1]. | ||||||||||||
| Name | SEMBL | ||||||||||||
| CAS | 1443448-82-5 | ||||||||||||
| Formula | C12H11NO4 | ||||||||||||
| Molar Mass | 233.22 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
|
||||||||||||
| Reference | [1]. Umezawa K, et al. Inhibition of matrix metalloproteinase expression and cellular invasion by NF-κB inhibitors of microbial origin. Biochim Biophys Acta Proteins Proteom. 2020;1868(6):140412. |