| Bioactivity | SDZ285428 is a CYP51 inhibitor. SDZ285428 inhibits Trypanosoma cruzi (TC) CYP51 with I/E2 Trypanosoma brucei (TB) CYP51 with I/E2 <1 (5 min) and I/E2=35 (1 h)[1]. | ||||||||||||
| In Vivo | Specific inhibition of protozoan CYP51 can potentially provide treatment for human trypanosomiases[1]. | ||||||||||||
| Name | SDZ285428 | ||||||||||||
| CAS | 174262-13-6 | ||||||||||||
| Formula | C24H20ClN3O | ||||||||||||
| Molar Mass | 401.89 | ||||||||||||
| Appearance | Solid | ||||||||||||
| Transport | Room temperature in continental US; may vary elsewhere. | ||||||||||||
| Storage |
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| Reference | [1]. Lepesheva GI, et al. CYP51: A major drug target in the cytochrome P450 superfamily. Lipids. 2008 Dec;43(12):1117-25. |