SDZ-MKS 492_product_DataBase

Bioactivity

SDZ-MKS 492 (MKS 492) is a selective inhibitor of cyclic GMP-inhibited phosphodiesterase (type III PDE). SDZ-MKS 492 inhibits antigen- or platelet activating factor (PAF)-induced bronchoconstriction and allergic reactions in guinea pigs and rats[1].

Target

type III phosphodiesterase

Invitro

MKS 492 relaxes airway smooth muscle in vitro[2].

In Vivo

MKS-492 (3-10 mg/kg; i.v.) inhibits antigen-induced bronchoconstriction in guinea pigs[1].MKS-492 (1-3 mg/kg; i.v.) inhibits PAF-induced bronchoconstriction and the increase in airway responsiveness to histamine in guinea pigs[1].MKS-492 (30-100 mg/kg; i.p.) inhibits leukotriene B4 (LTB4)-induced airway eosinophilia in guinea pigs[1].MKS-492 (10-100 mg/kg; i.p.) inhibits passive cutaneous anaphylaxis and mediator-induced skin reactions in rats[1]. Animal Model:

Name

SDZ-MKS 492

CAS

114606-56-3

Formula

C20H27N5O6

Molar Mass

433.46

Appearance

Solid

Transport

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Reference

[1]. Nagai H, et al. Effects of MKS-492 on antigen-induced bronchoconstriction and allergic reaction in guinea pigs and rats. Jpn J Pharmacol. 1993 Dec;63(4):405-13. [2]. Morley J, et, al. SDZ MKS 492. Agents Actions Suppl. 1991;34:403-10.

PeptideDB

SDZ-MKS 492

CAS: 114606-56-3 F: C20H27N5O6 W: 433.46