| Bioactivity | SDU-071 is a potent and orally active inhibitor of BRD4-p53 inhibitor. SDU-071 inhibits MDA-MB-231 cells proliferation with an IC50 of 10.5 μM. SDU-071 induces cell cycle arrest and apoptosis[1]. |
| Invitro | SDU-071 (10 μM, 24 h) 诱导 MDA-MB-231 细胞周期阻滞和凋亡[1]。SDU-071 (10 μM, 72 h) 对 MDA-MB-231 细胞增殖、迁移和侵袭有抑制作用[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> SDU-071 相关抗体: Apoptosis Analysis[1] Cell Line: |
| In Vivo | SDU-071 (250 mg/kg，灌胃；每日 1 次，连用 21 天) 抑制 MDA-MB-231 原位小鼠异种乳腺肿瘤模型的肿瘤生长[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. Animal Model: |
| Formula | C28H25N3O2 |
| Molar Mass | 435.52 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Wang S, et al. Novel BRD4-p53 Inhibitor SDU-071 Suppresses Proliferation and Migration of MDA-MB-231 Triple-Negative Breast Cancer Cells[J]. ACS Pharmacology & Translational Science, 2024. |