SDH-IN-3_product_DataBase

Bioactivity	SDH-IN-3 is a succinate dehydrogenase (SDH) inhibitor with an IC50 of 7.2 μg/mL. SDH-IN-3 exhibits excellent antifungal activities against Nigrospora oryzae with an EC50 of 1.9 μg/mL. SDH-IN-3 can be used for anti-infection research[1].
Target	IC50: 7.2 mg/L succinate dehydrogenase (SDH)
Invitro	SDH-IN-3(Compound T6) (40 μg/mL；6-7 天) 对水稻感染 N.oryzae mycelia 的体内保护活性和治疗活性分别为 81.5% 和 43.0%[1]。SDH-IN-3 (0-40 μg/mL；14-80 小时) 显著抑制 N.oryzae mycelia 菌丝的生长，还能有效阻碍孢子萌发和芽管伸长[1]。SDH-IN-3 (0-20 μg/mL；12-36 小时) 通过增加细胞膜通透性和导致细胞脂质过氧化来影响 N.oryzae mycelia 菌丝膜的完整性[1]。
Name	SDH-IN-3
CAS	2805297-11-2
Formula	C15H11F2N3OS
Molar Mass	319.33
Transport	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Reference	[1]. Zhang C, et.al. Design, Synthesis, and Study of the Dual Action Mode of Novel N-Thienyl-1,5-disubstituted-4-pyrazole Carboxamides against Nigrospora oryzae. J Agric Food Chem. 2023 May 17;71(19):7210-7220.

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