| Bioactivity | SDH-IN-2 is a potent succinate dehydrogenase (SDH) inhibitor with an IC50 of 0.55 μg/mL. SDH-IN-2 is also an antifungal agent. SDH-IN-2 inhibits phytopathogenic fungia with average EC50 values of 3.82-9.81 μg/mL for all the fungi[1]. |
| Invitro | SDH-IN-2 (Compound 13) (200 μg/mL, 7 days) 完全抑制苹果中 Physalospora piricola 感染，而且即使在 20 μg/mL 低浓度下对所有真菌也显示出 70.9-86.9% 的高抑制率[1]。SDH-IN-2 抑制 P. oryza 和 F. oxysporum f. sp. niveum 的 EC50 分别为 4.33 和 3.56 μg/mL[1]。SDH-IN-2 (0-50 μg/mL) 对豆类种子发芽率无影响[1].SDH-IN-2 (0-100 μg/mL) 对小麦幼苗的生长无显着影响[1].SDH-IN-2 抑制 SDH 酶活性，IC50 为 0.55 μg/mL[1]。SDH-IN-2 通过氢键与 SDH 的泛醌结合区较好地结合，发生 π-烷基相互作用和 π-阳离子相互作用[1]。 |
| In Vivo | SDH-IN-2 (化合物 13) (0-200 μg/mL，7 天) 抑制苹果上的 P. piricola 的感染[1]。 |
| Name | SDH-IN-2 |
| CAS | 1823354-06-8 |
| Formula | C10H6F3NO |
| Molar Mass | 213.16 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Zhang YH, et al. Discovery of N-Phenylpropiolamide as a Novel Succinate Dehydrogenase Inhibitor Scaffold with Broad-Spectrum Antifungal Activity on Phytopathogenic Fungi. J Agric Food Chem. 2023 Mar 1;71(8):3681-3693. |