| Bioactivity | SDH-IN-17 (compound C32), a hydrazide-containing flavonol derivative, is a potent succinate dehydrogenase (SDH) inhibitor with an IC50 of 8.42 μM. SDH-IN-17 can occupy the active site and form strong interactions with the key residues of SDH. SDH-IN-17 exhibits antifungal activity against Rhizoctonia solani (EC50=0.170 μg/mL). SDH-IN-17 disrupts the normal growth of hyphae by affecting the structural integrity of the cell membrane and cellular respiration. SDH-IN-17 has the potential for plant disease control research[1]. |
| Formula | C24H19BrN2O5 |
| Molar Mass | 495.32 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. Hongyi Chen, et al. Discovery of Novel Acethydrazide-Containing Flavonol Derivatives as Potential Antifungal Agents. J Agric Food Chem. 2024 Aug 7;72(31):17229-17239. |