| Bioactivity | SDH-IN-14 (Compound Z2) is an inhibitor of succinate dehydrogenase (SDH). SDH-IN-14 has antifungal activity (EC50=2.7 μg/mL) against B.cinerea. SDH-IN-14 acts by disrupting the integrity of the cell wall and cell membrane[1]. |
| Invitro | SDH-IN-14 (0-100 μg/mL; 12 h) 处理灰霉病菌，发现随着浓度的增加，细胞膜通透性增强[1]。SDH-IN-14 (0-200 μg/mL; 10 h) 处理灰霉病菌，发现 MDA 含量随浓度增加而增加，细胞膜受到氧化损伤[1]。SDH-IN-14 (12.5-100 μg/mL; 24 h) 处理灰霉病菌，发现浓度依赖性的抑制了 SDH 活性[1]。SDH-IN-14 (100 μg/mL) 的抗真菌抑制率分别为 96.7% (B.cinerea); 52.6% (R.solani); 69.9% (P.capsici); 59.2% (=S.sclerotiorum); 34.5% (=F.graminearum); 70.6% (Tomato Botrytis cinerea); 15.0% (=F.asiaticum)[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. 0 --> SDH-IN-14 相关抗体: |
| In Vivo | SDH-IN-14 (100; 200 μg/mL) 在蓝莓叶片上表现出良好的抗真菌活性，优于 Azoxystrobin (HY-B0849) 和 Fluopyram (HY-119459)[1]。 MCE has not independently confirmed the accuracy of these methods. They are for reference only. |
| Formula | C21H20N4O2S2 |
| Molar Mass | 424.54 |
| Transport | Room temperature in continental US; may vary elsewhere. |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
| Reference | [1]. He B, et al. Antifungal Activity of Novel Indole Derivatives Containing 1,3,4-Thiadiazole. J Agric Food Chem. 2024 May 8;72(18):10227-10235. |